(BPT) - When the COVID-19 pandemic hit in 2020, Ben, who had already been diagnosed with clinical depression in 2018, felt his depressive symptoms increase the more isolated he became. As an information technology consultant in New York City, his daily routine changed drastically. He woke up, immediately began work from bed and joined work meetings with his camera off with little to no participation.
Ben was in survival mode. Eventually, small tasks like showering, eating, sleeping, and attending meetings with his team felt overwhelming and close to impossible. After feeling like every day was a living nightmare, Ben decided to go to a new psychiatrist, who recommended he start taking antidepressants.
Finding the right treatment option isn't an easy task. Like many people with clinical depression, Ben struggled to find a treatment that worked for him. He cycled through a couple of medications but, to his dismay, none of his depressive symptoms were relieved. Impatient and frustrated, he couldn't believe it took a 12-week trial period for each new medication to see if it would work for him.
Eventually, after trying a few medications, Ben was diagnosed with treatment-resistant depression or TRD — a term that validated his experience cycling through a couple of treatments without relief. According to the Agency for Healthcare Research and Quality, TRD occurs when a patient has not achieved significant benefit with at least two different antidepressants of adequate dose and duration. Like Ben, about one-third of adults with depression may have this condition, according to a study published in the American Journal of Psychiatry.
Even with treatment and therapy, Ben continued to have depressive episodes. "One day, I received a last-minute meeting invite from my boss — I immediately went into a downward spiral," he said. "Curled in a ball and sobbing, my chest pain was so severe that I thought I was having a heart attack. I could see the hospital through my window but had no motivation to walk across the street and ask for help."
Soon after this episode, Ben moved across the country to live with his older sister in Oregon. Together, they researched many other treatment options. Ben was searching for a medication studied specifically to help someone like him and for the confidence that comes with a medicine approved by the U.S. Food and Drug Administration (FDA) specifically for his condition. During his search, he learned about a different treatment option for people diagnosed with TRD, called SPRAVATO® (esketamine) CIII nasal spray.
When he brought up this treatment option, Ben's psychiatrist walked him through the risks and benefits and administration and dosing requirements, which include going into a certified SPRAVATO® treatment center twice a week for the first four weeks of treatment. They also discussed some of the most serious side effects of this treatment, including dizziness, sedation, dissociation, increases in blood pressure, the risk of abuse and misuse, and increased risk of suicidal thoughts or actions. As with all SPRAVATO® patients, Ben was enrolled in the Risk Evaluation and Mitigation Strategy (REMS) program to track any serious side effects he may experience.
Please see the Important Safety Information, including BOXED WARNINGS, and a list of side effects below.
Once Ben was enrolled in the REMS program, he was able to start his twice-weekly SPRAVATO® treatments in conjunction with an oral antidepressant.
"I started to feel clearer and lighter as my depressive symptoms improved after my treatments, which gave me a new perspective," he said. "Through treatment and lots of work, my days are no longer completely consumed with self-hate and darkness but rather more self-love and light."
And, although this treatment may not work for everyone, SPRAVATO® became a key piece of Ben’s treatment plan to help him manage his TRD during one of the most difficult times in his life. Ben advises others who may be struggling to have open communication: “I understand how alone and isolated you may feel when you’re navigating depression, but just know you are not alone. Ask for help — your support system can help advocate for you when you’re unable to advocate for yourself.”
If you or someone you know needs mental health support, call or text 988 Suicide and Crisis Lifeline, available nationwide to people with a mental health counselor.
IMPORTANT SAFETY INFORMATION
What is SPRAVATO® (esketamine) CIII nasal spray?
SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth to treat:
SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe or effective as an anesthetic medicine.
It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO®.
It is not known if SPRAVATO® is safe and effective in children.
IMPORTANT SAFETY INFORMATION
Do not take SPRAVATO® if you:
If you are not sure if you have any of the above conditions, talk to your healthcare provider before taking SPRAVATO®.
Before you take SPRAVATO®, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Taking SPRAVATO® with certain medicine may cause side effects.
Especially tell your healthcare provider if you take central nervous system (CNS) depressants, psychostimulants, or monoamine oxidase inhibitors (MAOIs) medicines. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.
How will I take SPRAVATO®?
What should I avoid while taking SPRAVATO®?
Do not drive, operate machinery, or do anything where you need to be completely alert after taking SPRAVATO®. Do not take part in these activities until the next day following a restful sleep. See “What is the most important information I should know about SPRAVATO®?”
What are the possible side effects of SPRAVATO®?
SPRAVATO® may cause serious side effects including:
The most common side effects of SPRAVATO® when used along with an antidepressant taken by mouth include:
If these common side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.
These are not all the possible side effects of SPRAVATO®.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Ben is a volunteer with the SHARE Network, a Janssen Pharmaceuticals, Inc., program made up of people who are dedicated to inspiring others through their personal health journeys and stories of caring. He is a real patient with treatment-resistant depression and was compensated by Janssen Pharmaceuticals, Inc., for his time to develop this content.
If a Janssen treatment has made a difference in your life or the life of a loved one, we hope you will consider joining the SHARE Network.
Every story is unique. If you are an adult living with TRD, talk to your doctor to figure out a treatment plan that’s right for you.
This information is intended for the use of patients and caregivers in the United States and its territories only. Laws, regulatory requirements and medical practices in pharmaceutical products vary from country to country. The Prescribing Information included here may not be appropriate for use outside the United States and its territories.